Mathematical comparison between volume of distribution (V) and volume of distribution at steady-state (Vss) utilizing model-independent approach
โ Scribed by Eyal Sobol; Meir Bialer
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 62 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.372
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The steady state and terminal (area) volumes of distribution are important pharmacokinetic parameters defined as the ratio of the total quantity of drug in the body, A(b)(t), to drug plasma concentration C(p)(t) at steady state and the terminal phase of drug elimination, respectively. The general eq
The volume of distribution at steady state is considered to be one of the primary pharmacokinetic measurements obtained from in vivo experiments. This quantity is quite commonly calculated using moments of the observed concentration curve, the process being referred to as noncompartmental analysis.