The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug
✦ LIBER ✦
The urinary elimination „time lag”: Determination of the mean residence time from drug accumulation in the urine during infusion
✍ Scribed by Ronald A. Siegel
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 168 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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Based on disposition decomposition analysis (DDA), equations for the mean residence times (MRT) in the body are derived for a drug and its interconversion metabolite that undergo linear tissue distribution and linear or non-linear elimination from the central compartment after non-instantaneous admi