✍ Scribed by Konrad H Bleicher; Christian Lutz; Yves Wüthrich
No coin nor oath required. For personal study only.
The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9H-fluoren-9-yl)-phenoxy)pentanoic acid and their applications as new linkers for solid phase synthesis is reported. These supports show higher acid stability compared to standard trityl resins. Carboxylic acids and amines are immobilized and cleaved off after further modifications. TFA treatment releases the products in high yield and excellent purity.
📜 SIMILAR VOLUMES
A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase™ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor
Commercially available (+)-ct-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mits
The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and