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A novel, thioacetal based linker for solid-phase synthesis

✍ Scribed by Christoph M Huwe; Hermann Künzer

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
286 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Commercially available (+)-ct-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mitsunobu reactions, respectively. The products were easily cleaved from solid support by treatment with [bis(trifluoroacetoxy)iodo]benzene.

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