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Novel silyl linkers for solid-phase synthesis

✍ Scribed by Marco M. Meloni; R.C.D. Brown; Peter D. White; Duncan Armour

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 161 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01213-3

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✦ Synopsis

The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of 1°a lcohols, 2°alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3°alcohols to the solid-phase.

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