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A new silyl linker for reverse-direction solid-phase peptide synthesis

✍ Scribed by Bruce H Lipshutz; Young-Jun Shin

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
249 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Treatment of a free amino acid ester with CO 2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF in CH 3 CN leads to its free amine form which is isolated as a Boc derivative. The polymer support can be easily recycled.

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