𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new o-nitrobenzyl photocleavable linker for solid phase synthesis

✍ Scribed by Robert Rodebaugh; Bert Fraser-Reid; H. Mario Geysen


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
237 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


New phenylfluorenyl based linkers for so
✍ Konrad H Bleicher; Christian Lutz; Yves WΓΌthrich πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 119 KB

The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9H-fluoren-9-yl)-phenoxy)pentanoic acid and their applications as new linkers for solid phase synthesis is reported. These supports show higher acid stability compared to standard trityl resins. Carboxylic acids and amines are

New selenyl linker for solid-phase synth
✍ Kazuhiko Nakamura; Yuki Ohnishi; Eiji Horikawa; Takeo Konakahara; Masato Kodaka; πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 214 KB

A novel linker possessing selenocyanate and masked carboxylic acid was developed for the solid-phase synthesis of dehydropeptides. This linker was used to demonstrate the synthesis of the model compound of RGD-conjugated dehydropeptide.

A new silyl linker for reverse-direction
✍ Bruce H Lipshutz; Young-Jun Shin πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 249 KB

Treatment of a free amino acid ester with CO 2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF

PhFl acetic acid: A new linker for solid
✍ Konrad H. Bleicher; James R. Wareing πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 294 KB

A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in