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PhFl acetic acid: A new linker for solid phase organic synthesis

✍ Scribed by Konrad H. Bleicher; James R. Wareing

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
294 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified TFA treatment releases the corresponding products in high purity.

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A photolabile β€˜traceless’ linker for sol
A photolabile β€˜traceless’ linker for solid-phase organic synthesis
✍ James R Horton; Louise M Stamp; Anne Routledge πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 75 KB

A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient 'traceless' linker, revealing an aliphatic CH bond on photolysis at 350 nm. Methods for the synthesis, loading and photolytic cleavage of the linker are described.