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A photolabile ‘traceless’ linker for solid-phase organic synthesis

✍ Scribed by James R Horton; Louise M Stamp; Anne Routledge

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
75 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient 'traceless' linker, revealing an aliphatic CH bond on photolysis at 350 nm. Methods for the synthesis, loading and photolytic cleavage of the linker are described.

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