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Traceless Linkers-Only Disappearing Links in Solid-Phase Organic Synthesis?

✍ Scribed by Stefan Bräse; Stefan Dahmen


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
304 KB
Volume
6
Category
Article
ISSN
0947-6539

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✦ Synopsis


Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer-bound molecules, which can be cleaved from the resin leaving no residual functionality to bias the library. Various approaches based on different Group 14 to Group 16 heteroatoms have been developed in the past and used in new syntheses of diverse compound libraries.


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