An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis
β Scribed by Frank Stieber; Uwe Grether; Herbert Waldmann
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 154 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer-bound molecules, which can be cleaved from the resin leaving no residual functionality
A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhaseβ’ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor