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Acetophenone-based linker for solid-phase peptide synthesis

✍ Scribed by Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francesca Ercole; Firas Rasoul; Wayne Sampson; N. Joe Maeji

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 126 KB
Volume: 6
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(200002)6:2<49::aid-psc239>3.0.co;2-6

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✦ Synopsis

A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase™ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluoroacetic acid (TFA) in dichloromethane (DCM). Solid-phase syntheses of model decapeptides using this linker are described.

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