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Solid phase synthesis – designer linkers for combinatorial chemistry: a review

✍ Scribed by Kirsteen Gordon; Shankar Balasubramanian

Publisher: Wiley (John Wiley & Sons)
Year: 1999
Tongue: English
Weight: 289 KB
Volume: 74
Category: Article
ISSN: 0268-2575
DOI: 10.1002/(sici)1097-4660(199909)74:9<835::aid-jctb130>3.0.co;2-z

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✦ Synopsis

Solid phase organic synthesis is a rapidly expanding area of synthetic chemistry which is being widely exploited in the search for new biologically active compounds by combinatorial techniques. This review introduces the key concepts of solid phase methodology and combinatorial synthesis with particular focus on the issues that concern the development of linkers which are used to attach the substrate to the solid support.

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