Synthesis and applications of a new base-labile fluorene derived linker for solid-phase peptide synthesis
โ Scribed by Francesc Rabanal; Ernest Giralt; Fernando Albericio
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 593 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
## Abstract A new baseโlabile anchoring group, derived from 9โ(hydroxymethyl)fluoreneโ4โcarboxylic acid (HO~2~CFmoH or HOFmCO~2~H; 7), for polymerโsupported peptide synthesis os described. The synthesis of 7 starting from 2,2โฒโbiphenyldicarboxylic acid (**1**) proceeds in an overall yield of 53%. T
The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.