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A new safety-catch protecting group and linker for solid-phase synthesis

✍ Scribed by Sathiah Thennarasu; Chuan-Fa Liu

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
434 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.

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