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Safety-catch and multiply cleavable linkers in solid-phase synthesis

✍ Scribed by Marcel Pátek; Michal Lebl

Publisher
Wiley (John Wiley & Sons)
Year
1998
Tongue
English
Weight
176 KB
Volume
47
Category
Article
ISSN
0006-3525

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✦ Synopsis

This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and "small" organic molecules, as well as their limitations for particular chemistries and reaction conditions.

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