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Linkers for Solid-Phase Synthesis

✍ Scribed by Stefan Brase; Stefan Dahmen

Publisher: John Wiley and Sons
Year: 2003
Weight: 50 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200347262

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A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase™ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor