The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of 1Β°a lcohols, 2Β°alcohols and phenols to the solid ph
A novel linker strategy for solid-phase synthesis
β Scribed by J.Richard Morphy; Zoran Rankovic; David C. Rees
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 185 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Commercially available (+)-ct-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mits
A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 Β° or 2 Β° amine affords resin