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A Dde-based carboxy linker for solid-phase synthesis

✍ Scribed by Siri Ram Chhabra; Harendra Parekh; Azra N Khan; Barrie W Bycroft; Barrie Kellam

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 92 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00101-0

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✦ Synopsis

The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkephalin and Human Angiotensin II.

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