✦ LIBER ✦

Versatile Dde-based primary amine linkers for solid phase synthesis

✍ Scribed by Siri Ram Chhabra; Azra N. Khan; Barrie W. Bycroft

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 253 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00555-3

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A Dde-based carboxy linker for solid-pha

A Dde-based carboxy linker for solid-phase synthesis

✍ Siri Ram Chhabra; Harendra Parekh; Azra N Khan; Barrie W Bycroft; Barrie Kellam 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 92 KB

The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and

A New Versatile Linker for the Solid-Pha

A New Versatile Linker for the Solid-Phase Synthesis of Secondary Amines.

✍ Heiko Glatz; Willi Bannwarth 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 148 KB 👁 1 views

A new versatile linker for the solid-pha

A new versatile linker for the solid-phase synthesis of secondary amines

✍ Heiko Glatz; Willi Bannwarth 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 238 KB

A novel linker for the solid-phase synthesis of secondary amines based on an intramolecular cyclization was developed. The linker allows for a stepwise built-up of the secondary amines on the support. The feasibility was demonstrated in the parallel synthesis of a small set of different secondary am

New phenylfluorenyl based linkers for so

New phenylfluorenyl based linkers for solid phase synthesis

✍ Konrad H Bleicher; Christian Lutz; Yves Wüthrich 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 119 KB

The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9H-fluoren-9-yl)-phenoxy)pentanoic acid and their applications as new linkers for solid phase synthesis is reported. These supports show higher acid stability compared to standard trityl resins. Carboxylic acids and amines are

Acetophenone-based linker for solid-phas

Acetophenone-based linker for solid-phase peptide synthesis

✍ Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francesca Ercole; Firas Rasoul; Wayne 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhase™ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor

A novel, thioacetal based linker for sol

A novel, thioacetal based linker for solid-phase synthesis

✍ Christoph M Huwe; Hermann Künzer 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 286 KB

Commercially available (+)-ct-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mits