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A rapid and efficient synthesis of 2-deoxy-2-[18F]fluoroacetamido-D-mannopyranose and -D-galactopyranose

✍ Scribed by Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Kazuo Kubota; Takehiko Fujiwara; Hiroshi Sugiyama; Yoshinao Abe; Tachio Sato; Taiju Matsuzawa; Hiromu Takahashi; Akira Wakui; Tatsuo Ido

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
252 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Rapid and efficient syntheses of 2‐deoxy‐2‐[^18^F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [^18^F]fluoride and ethyl bromoacetate are described. [^18^F]Fluoride was produced by the ^18^O (p, n) ^18^F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

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