An efficient, one-pot synthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose (N-[18F]fluoroacetyl-D-glucosamine), potential diagnostic imaging agent

✍ Scribed by Masao Tada; Atsushi Oikawa; Ren Iwata; Takehiko Fujiwara; Kazuo Kubota; Taiju Matsuzawa; Hiroshi Sugiyama; Tatsuo Ido; Kiichi Ishiwata; Tachio Sato

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: French
• Weight: 277 KB
• Volume: 27
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580271111

✦ Synopsis

A rapid, one-pot synthesis of 2-deoxy-2-[18F] fluoroacetamido-D-glucopyranose (g-[ 18F] f luoroacetyl-D-glucosamine) (1) starting from [ 18F] fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation.

[18F]Fluoride was produced by the l 8 O (p, n) 1 8 F nuclear reaction using the cyclotron. The total synthesis time, th radiochemical yield, and purity of (A) are G . 90 mint z. 9.1%, and >98%, respectively. Sugar (1) showed the diagnost tumor-imaging activity.