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Use of ozonolysis in the synthesis of C-terminal peptide aldehydes on solid support

✍ Scribed by Catherine Pothion; Marielle Paris; Annie Heitz; Luc Rocheblave; Florence Rouch; Jean-Alain Fehrentz; Jean Martinez


Book ID
108385319
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
200 KB
Volume
38
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Synthesis of peptide aldehydes on solid
✍ Marielle Paris; annie Heitz; Vincent Guerlavais; MichΓ¨le Cristau; Jean-Alain Feh πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 204 KB

A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected or-amino aldehyde with MBHA-supported Wittig ou Winig-Horner reagent yielded resin-linked ~-~-unsaturated 8-amino derivative. After elongation of the peptide chain, ozonolysis produced fair

Solid Phase Synthesis of C-Terminal Pept
✍ Fehrentz, J. A.; Paris, M.; Heitz, A.; Velek, J.; Winternitz, F.; Martinez, J. πŸ“‚ Article πŸ“… 1997 πŸ› American Chemical Society 🌐 English βš– 275 KB
Synthesis of peptide aldehydes on solid
✍ Marielle Paris; Catherine Pothion; Laurent Goulleux; Annie Heitz; Jean Martinez; πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 162 KB
Solid phase synthesis of peptide C-termi
✍ Jennifer A. Patterson; Robert Ramage πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 179 KB

A new linker based on the dibenzosuberyl system was developed in order to synthesisΒ’ peptide Cterminal semicarbazones which can bΒ’ readily converted into peptide (7-terminal aldehydes. The method uses Fmoc-methodoiogy and proceeds with no loss of stereochemical integrity.