A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected or-amino aldehyde with MBHA-supported Wittig ou Winig-Horner reagent yielded resin-linked ~-~-unsaturated 8-amino derivative. After elongation of the peptide chain, ozonolysis produced fair
β¦ LIBER β¦
Use of ozonolysis in the synthesis of C-terminal peptide aldehydes on solid support
β Scribed by Catherine Pothion; Marielle Paris; Annie Heitz; Luc Rocheblave; Florence Rouch; Jean-Alain Fehrentz; Jean Martinez
- Book ID
- 108385319
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 200 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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