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Practical synthesis of peptide C-terminal aldehyde on a solid support

✍ Scribed by Konno, Hiroyuki; Sema, Yoshihiro; Ishii, Manabu; Hattori, Yasunao; Nosaka, Kazuto; Akaji, Kenichi

Book ID
120618670
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
554 KB
Volume
54
Category
Article
ISSN
0040-4039

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A new linker based on the dibenzosuberyl system was developed in order to synthesisΒ’ peptide Cterminal semicarbazones which can bΒ’ readily converted into peptide (7-terminal aldehydes. The method uses Fmoc-methodoiogy and proceeds with no loss of stereochemical integrity.