Solid phase synthesis of peptidyl aldehydes from C-terminal thiazolidinyl peptides
β Scribed by Nathalie Galeotti; Matthieu Giraud; Patrick Jouin
- Publisher
- Springer Netherlands
- Year
- 1997
- Tongue
- English
- Weight
- 172 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1573-3149
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π SIMILAR VOLUMES
A new linker based on the dibenzosuberyl system was developed in order to synthesisΒ’ peptide Cterminal semicarbazones which can bΒ’ readily converted into peptide (7-terminal aldehydes. The method uses Fmoc-methodoiogy and proceeds with no loss of stereochemical integrity.
## Abstract Solidβphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for
## Abstract In this paper, a straightforward and generic protocol is presented to label the __C__βterminus of a peptide with any desired moiety that is functionalized with a primary amine. Amineβfunctional molecules included are polymers (useful for hybrid polymers), long alkyl chains (used in pept