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Synthesis of peptide aldehydes on solid support using ozonolysis

✍ Scribed by Marielle Paris; annie Heitz; Vincent Guerlavais; Michèle Cristau; Jean-Alain Fehrentz; Jean Martinez

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 204 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01559-7

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✦ Synopsis

A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected or-amino aldehyde with MBHA-supported Wittig ou Winig-Horner reagent yielded resin-linked ~-~-unsaturated 8-amino derivative. After elongation of the peptide chain, ozonolysis produced fairly pure C-terminal peptide aldehydes in good yield.

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