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Treatment of Autoimmune Disease by Oral Tolerance to Autoantigens

✍ Scribed by Caroline C. Whitacre; Ingrid E. Gienapp; Abbie Meyer; Karen L. Cox; Najma Javed

Book ID: 112240864
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 132 KB
Volume: 80
Category: Article
ISSN: 1090-2341
DOI: 10.1006/clin.1996.0139

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ral tolerance describes the observation that a state of hyporesponsiveness follows immunization with a previously fed protein. It was first described in 1911 when Wells fed hen egg proteins to guinea-pigs and found them resistant to anaphylaxis when challengedL In 1946, Chase fed guinea-pigs the con