𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

✍ Scribed by Howard L. Weiner

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
909 KB
Volume
18
Category
Article
ISSN
0167-5699

No coin nor oath required. For personal study only.

✦ Synopsis

ral tolerance describes the observation that a state of hyporesponsiveness follows immunization with a previously fed protein. It was first described in 1911 when Wells fed hen egg proteins to guinea-pigs and found them resistant to anaphylaxis when challengedL In 1946, Chase fed guinea-pigs the contact-sensitizing agent dinitrochlorobenzene (DNCB) and observed that animals had decreased skin reactivity to DNCB (Ref. 2). Furthermore, numerous investigators showed that animals fed proteins such as ovalbumin (OVA) or sheep red blood cells do not respond as well to these antigens when subsequently immunized, but do respond normally to other antigens 3. The phenomenon P11S0, 67-5699( 97) 01053-0 J U L Y I 9 9 7 REVIEW IMMUNOLOGY TODAY ' !Oral administration of antigen GALT / ",.. Low dose High dose Induction of Th2 (IL-4/IL-10)-Deletion or anergy of and Th3 (TGF-~)-secreting Thl and Th2 cells regulatory ceils Active suppression Clonal deletion/anergy \ ./

πŸ“œ SIMILAR VOLUMES

Oral tolerance: Elucidation of mechanism
Oral tolerance: Elucidation of mechanisms and application to treatment of autoimmune diseases
✍ Elizabeth Fowler; Howard L. Weiner πŸ“‚ Article πŸ“… 1997 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 209 KB

Oral tolerance is the phenomenon of systemic, antigen specific, immunological hyporesponsiveness that results from oral administration of a protein. The mechanism by which tolerance is generated depends on the amount of antigen administered; low doses favor induction of regulatory T cells while high

Dendritic cells in tolerance induction f
Dendritic cells in tolerance induction for the treatment of autoimmune diseases
✍ Maria Rescigno πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 248 KB πŸ‘ 2 views

## Abstract Autoimmune diseases are characterized by the loss of tolerance toward self‐antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non‐spec

Autoimmune ovarian disease: mechanism of
Autoimmune ovarian disease: mechanism of disease induction and prevention
✍ KSK Tung; YH Lou; KM Garza; C Teuscher πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 690 KB

Investigation of the versatile models for autoimmunity of the ovary and other selected organs has contributed to our understanding of the following aspects of autoimmunity: the mechanism of T cell molecular mimicry; T--~B epitope spreading, as a basis for autoantibody diversification, and as a link

The Epigenetics of Autoimmune Diseases (
The Epigenetics of Autoimmune Diseases (Zouali/The Epigenetics of Autoimmune Diseases) || Post-Translational Modification of HMGB1 and Its Role in Immune Activation
✍ Zouali, Moncef πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley & Sons, Ltd 🌐 English βš– 356 KB πŸ‘ 1 views

The Role Of Epigenetic Mechanisms In Autoimmune Disease Is Only Now Starting To Become Clear. Understanding These Mechanisms, Their Effect On Cellular Function And The Role Of Environmental Factors Is Vital To Determining How To Manage These Often Debilitating And Fatal Diseases. drawing On The Res