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The TAL1 proto-oncogene: A critical mediator of T-cell acute lymphoblastic leukemia?

✍ Scribed by Robert O. Bash; R.Graham Smith; Richard Baer


Book ID
119143079
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
602 KB
Volume
14
Category
Article
ISSN
0197-1859

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Deregulated expression of the TAL1 gene
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TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL