✦ LIBER ✦

Deregulated expression of the TAL1 gene by t(1;5)(p32;q31) in patient with T-cell acute lymphoblastic leukemia

✍ Scribed by Sylvie François; Eric Delabesse; Laurence Baranger; Marie Dautel; Charles Foussard; Marc Boasson; Odile Blanchet; Olivier Bernard; Elizabeth A. Macintyre; Norbert Ifrah

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 239 KB
Volume: 23
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199809)23:1<36::aid-gcc6>3.0.co;2-7

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✦ Synopsis

TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL1, in which the breakpoint occurs approximately 10 kbp 5' to the gene and leads to transcriptional activation and synthesis of a TAL1 protein, and extends the spectrum of recognized TAL1 gene translocations associated with T-ALL.

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