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Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia

✍ Scribed by Hudan Liu; Mark Y. Chiang; Warren S. Pear


Book ID
107619341
Publisher
Carden Jennings Publishing
Year
2011
Tongue
English
Weight
305 KB
Volume
94
Category
Article
ISSN
0925-5710

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## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis