## Abstract __MLL__ (also known as __ALLβ1, HTRX__, or __HRX__) gene translocations are among the most common chromosomal abnormalities recognized in both Bβlineage acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, __MLL__ gene rearrangements are uncommon in Tβcell ALL.
Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia
β Scribed by A. Borkbardt; R. Repp; J. Harbott; C. Keller; F. Berner; J. Ritterbach; F. Lampert
- Book ID
- 105279736
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 449 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0939-5555
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## Abstract Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (MLβDS and DSβALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations charac
of a de novo Ph in T-cell acute leukemia. So this case could be the first de novo T-cell childhood ALL showing the expression of p210 protein associated with a very aggressive clinical evolution.
TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL