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Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia

✍ Scribed by A. Borkbardt; R. Repp; J. Harbott; C. Keller; F. Berner; J. Ritterbach; F. Lampert


Book ID
105279736
Publisher
Springer
Year
1992
Tongue
English
Weight
449 KB
Volume
64
Category
Article
ISSN
0939-5555

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TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL