TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells
β Scribed by Cardoso, B A; de Almeida, S F; Laranjeira, A B A; Carmo-Fonseca, M; Yunes, J A; Coffer, P J; Barata, J T
- Book ID
- 118160191
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 610 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0887-6924
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TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL
HSB-2 is a cell line derived from a patient who had T-cell acute lymphoblastic leukemia (T-cell ALL) with a t ( 1;7)(p34;q34). We used a genomic probe from the T-cell receptor beta (TCRB) locus (7q34) t o identify DNA rearrangements in HSB-2. Two rearranged Bglll DNA fragments were cloned, and one o