Ortho-and para-f luoro-a-methylstyrenes specifically 14C-labelled in all three positionsof the side chain have been synthesized by a modified Wittig reaction. synthesized as intermediates. The yields in all cases were good and any radiochemical impurities could be readily removed by careful fraction
The synthesis of α-methylstyrenes with 14C-labelling in the side chain
✍ Scribed by H. M. Ali; C. A. Barson; P. L. Coe
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 154 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
α‐Methylstyrenes with all three side chain carbons specifically ^14^C‐labelled have been synthesised by Wittig reactions between the appropriately labelled acetophenones or methylene triphenylphosphoranes. The yields in all cases were good and any radiochemical impurities could be readily removed by distillation.
📜 SIMILAR VOLUMES
## Abstract The preparation of 1‐[ (3′‐^14^C)‐Allyl]‐3,4‐methylene dioxy‐,1‐[(3′‐^14^C)‐allyl]‐3‐methoxy‐4,5‐methylene dioxy‐, and 1‐[(3′‐^14^C)‐allyl]‐3,4,5‐trimethaoxy benzenes is described. The ^14^C‐label was introduced into the 3′‐carbon of the allylic side chain via the Wittig reaction.
## Abstract The ring‐ and side‐chain‐^14^C‐labeled DL‐4,4′‐propylenedi‐2,6‐piperazinediones (I) were synthesized from chloroacetic acid‐1‐^14^C in two steps and from DL‐analine‐1‐^14^C in six steps, respectively. The radiochemical yield for the ring labeling was 24.5%; for the side‐chain labeling i
y-2H2]Estragole was synthesized [ methylene-112] -benzyl chloride; [ p-2H] estragole via reduction vinylation of 4-methoxy-2 of 3-(~-anisyl)-propyne with bis-3-methyl-2-butylborane (obtained from LiAl H4 , BF3 etherate and 2-methyl-2-butene) ; k-2H]estragole 2 ? y & cinnamaldehyde with NaBH3CN.
## Abstract Dimethoxymethyl phenobarbital (DMMP), labeled with ^14^C on the ring and side chains was prepared for drug metabolism studies. The synthesis of DMMP‐ethyl‐1–^14^C (4a) in four steps provided a 43% yield from ethyl‐1–^14^C iodide. The yields of DMMP‐2–^14^C (4b) and DMMP‐dimethylene‐^14^
## Abstract The synthesis of radiolabelled 4‐hydroxy‐3‐(3‐methyl‐3‐buten‐1‐ynyl) benzaldehyde (eutypine 1), a phytotoxic compound isolated from the culture media of the fungus __Eutypa lata__, responsible for vineyard die‐back, is described. The radioisotope ^14^C was introduced __via__ a Wittig re