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The synthesis of dimethoxymethyl phenobarbital labeled with 14C

✍ Scribed by Theodore S. T. Wang

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
190 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Dimethoxymethyl phenobarbital (DMMP), labeled with ^14^C on the ring and side chains was prepared for drug metabolism studies. The synthesis of DMMP‐ethyl‐1–^14^C (4a) in four steps provided a 43% yield from ethyl‐1–^14^C iodide. The yields of DMMP‐2–^14^C (4b) and DMMP‐dimethylene‐^14^C (4c) were 87.5% and 30% respectively.

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