The synthesis of 2H, 3H, 13C and 14C labelled Mepirzapine
β Scribed by F. Sperling; A. van Rooy; F.M. Kaspersen
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 66 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The preparation of [^3^H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [^13^C~3~]malonate was used to prepare [^13^C~3~]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [^14^C]Sch 727965 was prepared in five steps from diethyl [2
## Abstract ^3^HβSch 58235 was prepared at a specific activity of 29.1 Ci/mmol by Ir(COD)(Cy~3~P)PyPF~6~ catalysed exchange with tritium gas. ^14^CβSch 58235 was prepared in three steps from __p__βhydroxy[ringβUβ^14^C]benzaldehyde with an overall radiochemical yield of 21%. ^13^C~6~βSch 58235 was s
The syntheses of 1,2,3,4,10,1412-hexahydro-2-methylpyrazino[2,l-a]pyrido [2,3-c][2]benzazepine (Org 3770) labelled with 'H (and 'H), "C and I4C are described. Tritiated Org 3770 was prepared either by exchange under alkaline conditions with tritiated water or catalytic reductive dehalogenation of a
## Abstract ^2^H and ^3^H labelled Sch 40120 were prepared by Pt catalysed exchange with isotopic water. D7βSch 40120 was obtained in two exchanges in 53% yield and ^3^HβSch 40120 was prepared by a single exchange at a specific activity of 19.8 Ci/mmole. ^14^CβSch 40120 was prepared in 4 steps from