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The synthesis of org 3770 labelled with 3H, 13C AND 14C

โœ Scribed by Frans M. Kaspersen; Fons A. M. Van Rooij; Eric G. M. Sperling; Joop H. Wieringa

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
597 KB
Volume
27
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

The syntheses of 1,2,3,4,10,1412-hexahydro-2-methylpyrazino[2,l-a]pyrido [2,3-c][2]benzazepine (Org 3770) labelled with 'H (and 'H), "C and I4C are described. Tritiated Org 3770 was prepared either by exchange under alkaline conditions with tritiated water or catalytic reductive dehalogenation of a chloro analogue with 'H2. "C-labelled material was obtained in a seven-step synthesis starting from ' C-labelled benzene whereas ' C-Org 3770 was prepared in a three-step synthesis starting with 14C0,. All labelled compounds were analyzed by TLC, HPLC, MS and NMR.

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