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The synthesis and larvicidal activity of N -aroyl- N ′-(5-aryl-2-furoyl)ureas

✍ Scribed by Yang, Xin-Ling; Wang, Dao-Quan; Chen, Fu-Heng; Zhang, Zhong-Ning

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
147 KB
Volume
52
Category
Article
ISSN
1526-498X

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✦ Synopsis

A novel type of diarolyurea compound containing a furan ring has been designed and prepared. Thus, a series of N-aroyl-N@-(5-aryl-2-furoyl)ureas were synthesized by a nucleophilic addition reaction between 5-substituted furamide and aroyl isocyanate in high yield ([80%). Their structures were con-Ðrmed by IR, [1H]NMR and elemental analyses. Bioassay showed that some of them exhibited activity against second-instar larvae of the yellow fever mosquito (Aedes aegypti L.). With the aid of artiÐcial neural network combined with multivariable regression, a preliminary study was made of structureÈactivity relationship.

1998 SCI.

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