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Synthesis and Morphine Enhancement Activity of N-[5-(2-phenoxyphenyl)-1, 3, 4-oxadiazole-2-yl]-N′-phenylurea Derivatives

✍ Scribed by Ali Almasi Rad; Majid Sheikhha; Rohollah Hosseini; Sayyed Abbas Tabatabaic; Abbas Shafiee

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 98 KB
Volume: 337
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200300822

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✦ Synopsis

Abstract

The synthesis of N‐[5‐(2‐phenoxyphenyl)‐1, 3, 4‐oxadiazole‐2‐yl]‐N′‐phenylurea derivatives is reported. The structures of these compounds are supported by their IR, ^1^H‐NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L‐365, 260, a known 3‐ureido‐1, 4‐benzodiazepine CCK‐B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a, 8c, 8h—8j, 8l, 8o have significant effects.

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