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Synthesis and Antimicrobiological Activity of N-Aryl-substituted 2-Methyl-3-carbethoxy-5-pyrrolinone Derivatives

✍ Scribed by Fina Lovren; Igor D. Gaon; Blanka Bobarevic


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
218 KB
Volume
323
Category
Article
ISSN
0365-6233

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✦ Synopsis


Abstract

We describe the synthesis of N‐aryl‐2‐methyl‐3‐carbethoxy‐5‐pyrrolinones benzylidene derivatives, their condensation with azomethines and substitution with aniline. The compounds have been tested for antimicrobial and fungicide activity: they have better fungicidal than bactericidal activity.


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✍ Bakr F. Abdel-Wahab; Hatem A. Abdel-Aziz; Essam M. Ahmed 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB 👁 2 views

## Abstract The reaction of ethyl 4‐(benzofuran‐2‐yl)‐2,4‐dioxobutanoate **2** with two moles of hydrazine hydrate afforded 5‐(benzofuran‐2‐yl)‐1__H__‐pyrazole‐3‐carbohydrazide **4a**, while its reaction with equimolar amount of phenylhydrazine gave ester **3b** which then converted to 5‐(benzofura