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Synthesis and Antibacterial Activity of 1β-Methyl-2-(5-substituted oxadiazolo pyrrolidin-3-yl-thio)carbapenem Derivatives

✍ Scribed by Chang-Hyun Oh; Hyun-Gu Dong; Joo-Shin Lee; Su-Chul Lee; Joon Hee Hong; Jung-Hyuck Cho


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
189 KB
Volume
336
Category
Article
ISSN
0365-6233

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## Abstract The reaction of ethyl 4‐(benzofuran‐2‐yl)‐2,4‐dioxobutanoate **2** with two moles of hydrazine hydrate afforded 5‐(benzofuran‐2‐yl)‐1__H__‐pyrazole‐3‐carbohydrazide **4a**, while its reaction with equimolar amount of phenylhydrazine gave ester **3b** which then converted to 5‐(benzofura