Convenient Synthesis and Antimicrobial Activity of New 3-Substituted 5-(Benzofuran-2-yl)-pyrazole Derivatives

✍ Scribed by Bakr F. Abdel-Wahab; Hatem A. Abdel-Aziz; Essam M. Ahmed

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 474 KB
• Volume: 341
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200800119

✦ Synopsis

Abstract

The reaction of ethyl 4‐(benzofuran‐2‐yl)‐2,4‐dioxobutanoate 2 with two moles of hydrazine hydrate afforded 5‐(benzofuran‐2‐yl)‐1__H__‐pyrazole‐3‐carbohydrazide 4a, while its reaction with equimolar amount of phenylhydrazine gave ester 3b which then converted to 5‐(benzofuran‐2‐yl)‐1‐phenyl‐1__H__‐pyrazole‐3‐carbohydrazide 4b. Various new compounds such as imides 5 and 6, acyl hydrazones 7 and 8, bi‐pyrazoles 9‐12, and 1,3‐thiazole derivatives 14 and 15 were prepared from carbohydrazide derivatives 4a, b. The new compounds are tested for their antimicrobial activity. Compounds 2, 5, 7, and 8 showed antifungal activities against C. albicans. Also, compounds 2, 6, 8, and 15 showed antibacterial activities.