## Abstract Ten new (5‐chloro‐2(3H)‐benzothiazolon‐3‐yl)propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1‐[3‐(5‐chloro‐2(3H)
✦ LIBER ✦
Synthesis and Antinociceptive Activity of (5-Chloro-2-benzothiazolinon-3-yl)acetamide Derivatives
✍ Scribed by T. Önkol; D. S. Dogruer; S. Ito; M. F. Sahin
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 52 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0365-6233
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## Abstract The reaction of ethyl 4‐(benzofuran‐2‐yl)‐2,4‐dioxobutanoate **2** with two moles of hydrazine hydrate afforded 5‐(benzofuran‐2‐yl)‐1__H__‐pyrazole‐3‐carbohydrazide **4a**, while its reaction with equimolar amount of phenylhydrazine gave ester **3b** which then converted to 5‐(benzofura