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Synthesis and Antinociceptive Activity of (5-Chloro-2(3H)-benzothiazolon-3-yl)propanamide Derivatives

✍ Scribed by Tijen Önkol; Engin Yildirim; Kevser Erol; Shigero Ito; M. Fethi Şahin

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 92 KB
Volume: 337
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200300863

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✦ Synopsis

Abstract

Ten new (5‐chloro‐2(3H)‐benzothiazolon‐3‐yl)propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1‐[3‐(5‐chloro‐2(3H)‐benzothiazolon‐3‐yl)‐propanoyl]‐4‐(4‐chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.

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