Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted
Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives
✍ Scribed by Giuseppe Daidone; Demetrio Raffa; Benedetta Maggio; Fabiana Plescia; Vincenza Maria Catena Cutuli; Nunzio Guido Mangano; Antonina Caruso
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 51 KB
- Volume
- 332
- Category
- Article
- ISSN
- 0365-6233
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A variety of 3-(4-methyl phenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4one was synthesi