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Synthesis and Antitumour Activity of 1H,3H-Thiazolo[3,4-a]benzimidazole Derivatives

✍ Scribed by Alba Chimirri; Pietro Monforte; Laura Musumeci; Angela Rao; Maria Zappalà; Anna-Maria Monforte

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
45 KB
Volume
334
Category
Article
ISSN
0365-6233

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✍ Demetrio Raffa; Giuseppe Daidone; Benedetta Maggio; Domenico Schillaci; Fabiana 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 2 views

Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted