Synthesis and Pharmacological Evaluation of Some 3-(4-Methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as Analgesic and Anti-inflammatory Agents

✍ Scribed by Veerachamy Alagarsamy; Durairaj Shankar; Muthuvel Murugan; Anees Ahmed Siddiqui; Ramadoss Rajesh

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 330 KB
• Volume: 340
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200600189

✦ Synopsis

A variety of 3-(4-methyl phenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4one was synthesized from 4-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds A1, A2, and A3 showed more potent analgesic activity and the compound A3 showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.