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Synthesis of N-Aryl-N′-heteroaryl-Substituted Urea and Thiourea Derivatives and Evaluation of Their Anticonvulsant Activity

✍ Scribed by Gottfried Heinisch; Barbara Matuszczak; Dietmar Rakowitz; Boonyong Tantisira

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
338 KB
Volume
330
Category
Article
ISSN
0365-6233

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✦ Synopsis

Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were found to be convulsants per se.

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