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Synthesis and CNS Activity of N,N-Disubstituted 1-(Aminomethyl)-5-alkyl-3-(aryloxyacetylhydrazono)indolin-2-ones

✍ Scribed by Rajesh Agarwal; Shobha Misra; Rajiv K. Satsangi; Shiva S. Tiwari

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 245 KB
Volume: 315
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19823150207

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Isatin and 5‐methylisatin were condensed with various aryloxyacetylhydrazides to furnish the 3‐(aryloxyacetylhydrazono)‐5‐alkylindolin‐2‐ones 1–4. When 1–4 were subjected to Mannich reaction, the N,N‐disubstituted 1‐(aminomethyl)‐5‐alkyl‐3‐(aryloxyacetylhydrazono)indolin‐2‐ones 5–8 were obtained. The compounds were CNS active and relatively non‐toxic (albino mice).

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