✦ LIBER ✦

The synthesis and biological evaluation of hypericin analogs

✍ Scribed by George A. Kraus; Weijiang Zhang; Susan Carpenter; Yvonne Wannemuehler

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 182 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00458-6

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and biological evaluation of n

Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

✍ Arun K. Ghosh; Zachary L. Dawson; Deuk Kyu Moon; Ruoli Bai; Ernest Hamel 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 393 KB

Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compo

Total synthesis and biological evaluatio

Total synthesis and biological evaluation of marinopyrrole A and analogs

✍ K.C. Nicolaou; Nicholas L. Simmons; Jason S. Chen; Nina M. Haste; Victor Nizet 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 305 KB

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

Synthesis and Biological Evaluation of T

Synthesis and Biological Evaluation of Two Mannose 6-Phosphate Analogs

✍ Sébastien Vidal; Carole Vidil; Alain Morère; Marcel Garcia; Jean-Louis Montero 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 332 KB 👁 3 views

Phosphonate analogs / Mannose 6-phosphate (M6P) / Receptors / Recognition markers / Phosphonates / Natural products Two β-hydroxyphosphonate analogs of M6P have been prepared by condensation of the lithiated anion of methyldiethylphosphonate with the C-6 carbonyl of a mannose derivative. The diaster

Synthesis and Biological Evaluation of C

Synthesis and Biological Evaluation of Cyclopropyl Analogs of the Antiestrogen MER 25

✍ Lynette B. Overacre; Robert A. Magarian 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 275 KB

In an effort to prepare effective nonsteroidal antiestrogens without intrinsic estrogenicity and with greater antagonism than the triarylethylenes (tamoxifen), four (E)-and (Z)-1,1dichloro-2-phenyl-2-[4-(2-diethylaminoethoxy)phenyl]-3-(4-methoxyphenyl)cyclopropane analogs of the antiestrogen MER 25,

Synthesis and biological evaluation of n

Synthesis and biological evaluation of new arylthiophene analogs of DuP 753

✍ Geneviève Estenne; Pierre Dodey; Patrice Renaut; Gérard Leclerc 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 161 KB

We described synthesis and biological results of analogs of DuP 753 where the central phenyl ring has been replaced by a 2,5-disubstituted thiophene.

Paclitaxel analogs modified in ring C: S

Paclitaxel analogs modified in ring C: Synthesis and biological evaluation

✍ Xian Liang; David G.I. Kingston; Byron H. Long; Craig A. Fairchild; Kathy A. Joh 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 1017 KB

Lead tetraeetate oxidation of 6u-hydmxy-7-epi-paclitaxel leads to C-.or-paclitaxel and C-seco-paclitaxel derivatives. Tetrapropylammonium perruthenate (TPAP) oxidation of a 6tx-hydroxy-7-epi-paclitaxel derivative leads to a 6-formyl-C-nor-paclitaxel derivative. Reaction of a 6ot-O-trifluoromethanesu